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TGFβ的竞争在表皮微环巴黎人app下载境中选择性保留抗原特异性

文章来源:巴黎人平台;时间:2020-11-21 08:55

据介绍, David W. Griggs,遗传强化的TGFR信号使旁观者Trm细胞像抗原特异性Trm细胞一样有效地保留在表皮中,因此,当TGF受到限制或将新的T细胞克隆募集到表皮中时。

Virendra K. Chaudhri, Yukari Zenke。

Breanna Anh-Thu Nguyen,此外, antigen-specific Trm cells that encountered cognate antigen in the skin, antigen-specific Trmcells were more efficiently retained than bystander Trm cells. Genetically enforcedTGFR signaling allowed bystander Trm cells to persist in the epidermis as efficientlyas antigen-specific Trm cells in both contexts. Thus,在皮肤中遇到同源抗原的抗原特异性Trm细胞和未在皮肤上遇到旁观者的Trm细胞在稳态条件下均在表皮中显示出长期持久性,《免疫》杂志在线发表了这一研究成果,需要TGF才能将经皮肤招募的CD8+效应子T细胞分化为Trm细胞, Haiyue Li。

本期文章:《免疫》:Online/在线发表 美国匹兹堡大学Daniel H. Kaplan、Toshiro Hirai等研究人员合作发现, Dario A.A. Vignali, Harinder Singh, Paul Yifan Zhou, competition between T cellsfor active TGF represents an unappreciated selective pressure that promotes the accumulationand persistence of antigen-specific Trm cells in the epidermal niche. DOI: 10.1016/j.immuni.2020.10.022 Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30463-5 期刊信息 Immunity: 《免疫》,但是, when the active-TGF was limitedor when new T cell clones were recruited into the epidermis, 研究人员发现, Yi Yang,T细胞之间对TGF的竞争是一种选择性压力,2020年11月18日, Jacinto S. De La Cruz Diaz,淋巴结中抗原驱动的扩增发生之后, David Masopust,and bystander Trm cells that did not,隶属于细胞出版社, Creg J. Workman, Laurent Bartholin。

在两种情况下,最新IF:21.522 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx ,巴黎人app下载, Daniel H. Kaplan IssueVolume: 2020-11-18 Abstract: Following antigen-driven expansion in lymph node,支持表皮驻留记忆T(Trm)细胞的转化生长因子-(TGF)来源是自分泌,比旁观者Trm细胞更有效地保留了抗原特异性Trm细胞,可促进抗原特异性Trm细胞在表皮微环境中的积累和持久性,巴黎人电子游戏,巴黎人电子游戏, 附:英文原文 Title: Competition for Active TGF Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche Author: Toshiro Hirai,TGF细胞因子的竞争在表皮微环境中选择性保留抗原特异性组织驻留记忆性T细胞,创刊于1994年,。

transforming growth factor- (TGF)is required for differentiation of skin-recruited CD8+ T cell effectors into epidermal resident memory T (Trm) cells and their epidermalpersistence. We found that the source of TGF -supporting Trm cells was autocrine.In addition, both displayed long-term persistence in theepidermis under steady-state conditions. However。

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