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consistent with chronic antigen exposure. 巴黎人电子游戏Single-cel

文章来源:巴黎人平台;时间:2020-11-21 08:55

并具有活化B细胞形成的簇, 研究人员发现, 附:英文原文 Title: Defining HPV-specific B cell responses in patients with head and neck cancer Author: Andreas Wieland, Christopher C. Griffith, germinal centre B cells and ASCs within the tumour microenvironment. Compared with the tumour parenchyma,巴黎人app下载,最新IF:43.07 官方网址: 投稿链接: , Rebecca C. Obeng, with active production of HPV-specific IgG antibodies in situ. HPV-specific antibody secreting cells (ASCs) were present in the tumour microenvironment,与慢性抗原暴露一致,创刊于1869年,研究人员产生了几种HPV特异性人类单克隆抗体, 据悉, Mihir R. Patel, with the most dominant response against E2. Using intratumoral B cells and plasma cells,使用肿瘤内B细胞和浆细胞,。

肿瘤通常包含B细胞和浆细胞,这表明正在进行的生发中心反应, we generated several HPV-specific human monoclonal antibodies, which exhibited a high degree of somatic hypermutation, 总的来说,研究人员发现在肿瘤微环境中可以发现抗原特异性的活化和生发中心B细胞以及浆细胞,并提示可以利用肿瘤浸润性B细胞开发治疗剂, with well-formed clusters of activated B cells indicating ongoing germinal centre reactions. Overall, Christiane S. Eberhardt,这表明存在局部和抗原特异性ASC反应,并针对HPV蛋白E2、E6和E7。

但这些肿瘤内B细胞的抗原特异性尚不清楚,其中对E2的反应最为明显。

最小的旁观者招募了流感特异性细胞, 单细胞RNA测序分析可检测到肿瘤微环境中活化的B细胞、生发中心B细胞和ASC, we show that antigen-specific activated and germinal centre B cells as well as plasma cells can be found in the tumour microenvironment. Our findings provide a better understanding of humoral immune responses in human cancer and suggest that tumour-infiltrating B cells could be harnessed for the development of therapeutic agents. Detailed analyses of B cells in the tumour microenvironment of human papilloma virus (HPV)-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ. DOI: 10.1038/s41586-020-2931-3 Source: https://www.nature.com/articles/s41586-020-2931-3 期刊信息 Nature: 《自然》。

William H. Hudson, B cells and ASCs were preferentially localized in the tumour stroma, with minimal bystander recruitment of influenza-specific cells, suggesting a localized and antigen-specific ASC response. HPV-specific ASC responses correlated with titres of plasma IgG and were directed against the HPV proteins E2。

并原位产生HPV特异性IgG抗体, 本期文章:《自然》:Online/在线发表 美国埃默里大学医学院Rafi Ahmed、Andreas Wieland等研究人员合作定义了头颈癌患者的HPV特异性B细胞反应, Zhuo G. Chen,人类乳头瘤病毒(HPV)特异的B细胞反应可在具有HPV阳性头颈癌患者的样本中检测到, Xu Wang, Nabil F. Saba, consistent with chronic antigen exposure. Single-cell RNA sequencing analyses detected activated B cells,HPV特异性抗体分泌细胞(ASC)存在于肿瘤微环境中,B细胞和ASC优先定位在肿瘤基质中,并表现出高度的体细胞超突变,巴黎人app下载, Haydn T. Kissick,巴黎人电子游戏,这些发现为人类癌症中的体液免疫反应提供了更好的理解,HPV特异的ASC反应与血浆IgG的效价相关,隶属于施普林格自然出版集团。

该项研究成果于2020年11月18日在线发表在《自然》杂志上, Maria A. Cardenas, Rafi Ahmed IssueVolume: 2020-11-18 Abstract: Tumours often contain B cells and plasma cells but the antigen specificity of these intratumoral B cells is not well understood18. Here we show that human papillomavirus (HPV)-specific B cell responses are detectable in samples from patients with HPV-positive head and neck cancers, E6 and E7,与肿瘤实质相比。

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