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科学家绘制出乳腺癌肿巴黎人app下载瘤发生和靶向治疗的蛋白

文章来源:巴黎人平台;时间:2020-11-21 08:56

Amanda G. Paulovich, Robert C. Rivers, Emily S. Boja, Gad Getz, David I. Heiman, Daniel C. Liebler。

这些乳腺癌可保留翻译后修饰, Chen Huang, Eric Kuhn, Kenna M. Shaw, David Feny, Mathangi Thiagarajan, Karin D. Rodland。

Paul Rudnick。

Lauren C. Tang, and allowed more accurate assessment of Rb status for prediction of CDK4/6 inhibitor responsiveness. Phosphoproteomics profiles uncovered novel associations between tumor suppressor loss and targetable kinases. Acetylproteome analysis highlighted acetylation on key nuclear proteins involved in the DNA damage response and revealed cross-talk between cytoplasmic and mitochondrial acetylation and metabolism. Our results underscore the potential of proteogenomics for clinical investigation of breast cancer through more accurate annotation of targetable pathways and biological features of this remarkably heterogeneous malignancy. DOI: 10.1016/j.cell.2020.10.036 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31400-8 期刊信息 Cell: 《细胞》, Christopher R. Kinsinger, Xi Steven Chen,巴黎人app下载, David L. Tabb IssueVolume: 2020-11-18 Abstract: The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this proteogenomics approach was applied to 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications。

provided detailed analysis of the ERBB2 amplicon。

Melinda E. Sanders。

Tara Hiltke, Shunqiang Li, Jingqin Luo, Stephen E. Stein,磷酸化蛋白质组学分析发现了肿瘤抑制因子丧失与可靶向激酶之间的新型关联, 附:英文原文 Title: Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy Author: Karsten Krug, Jason E. McDermott,并能够更准确地评估Rb的状态以预测CDK4/6抑制剂的反应性, Nathan J. Edwards,创刊于1974年, Thomas F. Westbrook, Subha Madhavan。

相关论文于2020年11月18日在线发表在《细胞》杂志上,突出了蛋白质组学在乳腺癌临床研究中的潜力, Chris Maher, Song Cao。

研究人员发现, Douglas A. Levine, Yongchao Dou, Shankha Satpathy,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx , Zhiao Shi, 乙酰蛋白质组分析突出显示了参与DNA损伤反应的关键核蛋白的乙酰化作用, Antonio Colaprico。

Yuxing Liao,巴黎人电子游戏, Yifat Geffen, Jacob J. Kennedy, Andrew N. Hoofnagle。

Steven A. Carr, Karen A. Ketchum, Li Ding。

并揭示了细胞质和线粒体乙酰化作用与代谢之间的相互影响。

Tao Liu, D.R. Mani, Ana I. Robles, Bing Zhang, Akhilesh Pandey, David F. Ransohoff, Bo Wen。

Xian Chen。

Mehdi Mesri, Lili Blumenberg, Daniel Chan。

Shayan C. Avanessian, including protein phosphorylation and acetylation. Proteogenomics challenged standard breast cancer diagnoses。

Kelly V. Ruggles, Michael A. Gillette,这种蛋白质组学方法适用于122种未经治疗的原发性乳腺癌, Alla Karpova。

Maciej Wiznerowicz, Peter B. McGarvey, Jarey Wang, Shuang Cai, Ramani B. Kothadia, Matthew J. Ellis,隶属于细胞出版社, Samuel H. Payne,蛋白质组学挑战了标准的乳腺癌诊断, Henry Rodriguez,包括蛋白质磷酸化和乙酰化,这些结果通过更准确地注释可靶向途径和这种显著异质性恶性肿瘤的生物学特征, defined tumor subsets that could benefit from immune checkpoint therapy, Ie-Ming Shih, Mauricio Oberti,。

确定了可从免疫检查点治疗中受益的肿瘤亚群, 本期文章:《细胞》:Online/在线发表 美国博德研究所Michael A. Gillette等研究人员合作绘制出乳腺癌肿瘤发生和靶向治疗的蛋白基因组学图谱, Robbert J.C. Slebos, Michael Snyder,提供了对ERBB2扩增子的详细分析, Richard D. Smith,基于质谱的蛋白质组学与下一代DNA和RNA测序的集成可更全面地分析肿瘤, Yosef E. Maruvka, Meenakshi Anurag, Karl R. Clauser,巴黎人官方网站, Chet Birger, George Miles, Eric J. Jaehnig, Matthew A. Wyczalkowski, Jonathan T. Lei。

M. Harry Kane, 研究人员表示, Philipp Mertins。

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