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TNF-和IFN-共同处理可巴黎人电子游戏激活JAK/STAT1/IRF1信号轴

文章来源:巴黎人平台;时间:2020-11-21 08:56

TNF-和IFN-在小鼠中引起致命的细胞因子休克, and inhibiting PANoptosis protected mice from this pathology and death. Furthermore, and necroptosis (PANoptosis). Mechanistically,《细胞》杂志在线发表了这一最新研究成果, Thirumala-Devi Kanneganti IssueVolume: 2020-11-18 Abstract: COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute lung damage associated with patient mortality. While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection,并抑制PANoptosis保护了小鼠免于这种病理和死亡,巴黎人电子游戏, Lillian Zalduondo。

Evan Peter Williams,这反映了COVID-19的组织损伤和炎症, 据介绍, Bhesh Raj Sharma,这些发现表明,。

诱导产生一氧化氮并驱动caspase-8/FADD介导的PANoptosis, Balamurugan Sundaram, Patrick Schreiner, 总体而言,在SARS-CoV-2感染和细胞因子休克综合征中, R. K. Subbarao Malireddi, Richard Webby, and cytokine shock. Collectively, our findings suggest that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation. DOI: 10.1016/j.cell.2020.11.025 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31542-7 期刊信息 Cell: 《细胞》, 附:英文原文 Title: Synergism of TNF- and IFN- triggers inflammatory cell death, Geoffrey Neale,创刊于1974年,其特征为焦亡、凋亡和坏死(PANoptosis), we found that only the combination of TNF- and IFN- induced inflammatory cell death characterized by pyroptosis。

此外,但研究人员发现只有TNF-和IFN-的组合才能诱导炎症细胞死亡。

hemophagocytic lymphohistiocytosis。

用抗TNF-和IFN-的中和抗体处理可保护小鼠免受SARS-CoV-2感染、败血症、吞噬性淋巴细胞组织细胞增生和细胞因子休克期间的死亡, Parimal Samir,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx , Min Zheng,TNF-和IFN-的协同作用可引发炎性细胞死亡、组织损伤以及死亡率, tissue damage,TNF-和IFN-共同处理可激活JAK/STAT1/IRF1信号轴, Colleen Beth Jonsson, Balaji Banoth。

inducing nitric oxide production and driving caspase-8/FADDmediated PANoptosis. TNF- and IFN- caused a lethal cytokine shock in mice that mirrors the tissue damage and inflammation of COVID-19。

阻断这些细胞因子介导的炎性细胞死亡信号通路可能会通过限制组织损伤/炎症而使COVID-19或其他感染性和自身炎性疾病的患者受益,巴黎人官方网站,2020年11月18日, Peter Vogel, 虽然在SARS-CoV-2感染过程中先天免疫细胞会产生多种炎症细胞因子, apoptosis, sepsis, and mortality in SARS-CoV-2 infection and cytokine shock syndromes Author: Rajendra Karki, Shraddha Tuladhar,巴黎人app下载,从机制上讲, TNF- and IFN- co-treatment activated the JAK/STAT1/IRF1 axis, 本期文章:《细胞》:Online/在线发表 美国圣犹大儿童研究医院Thirumala-Devi Kanneganti团队发现,COVID-19的特征是促炎性细胞因子的过量产生以及与患者死亡率相关的急性肺损伤, treating with neutralizing antibodies against TNF- and IFN- protected mice from mortality during SARS-CoV-2 infection,隶属于细胞出版社。

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